Welcome to the Bhagwat Lab

The research in our group is focused on elucidating DNA damage caused by endogenous reactive chemical
species and cellular processes such as DNA methylation, transcription, replication, and cytosine deamination
due to human AID/APOBEC enzymes. This causes mutations, strand breaks and genome instability. We study
the interplay between these processes and DNA repair in the prevention and promotion of human cancers.


Our multidisciplinary approach to understanding mutagenesis includes use of mass-spectrometry,
chemical synthesis, protein and nucleic acid biochemistry, genetics and cutting-edge cellular
and molecular biology methods including genomics and bioinformatics.